Journal
CELL CYCLE
Volume 18, Issue 12, Pages 1295-1301Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15384101.2019.1617454
Keywords
Poly(ADP-ribose) polymerase 3; EMT; mTORC2; cancer aggressiveness
Categories
Funding
- Association pour la Recherche contre le Cancer
- Ligue Nationale Contre le Cancer
- CNRS
- Universite de Strasbourg
- Ramon Areces Foundation
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Poly(ADP-ribose) polymerase 3 (PARP3) is the third member of the PARP family that catalyze a post-translational modification of proteins to promote, control or adjust numerous cellular events including genome integrity, transcription, differentiation, cell metabolism or cell death. In the late years, PARP3 has been specified for its primary functions in programmed and stress-induced double-strand break repair, chromosomal rearrangements, transcriptional regulation in the zebrafish and mitotic segregation. Still, deciphering the therapeutic value of its inhibition awaits additional investigations. In this review, we discuss the newest advancements on the specific functions of PARP3 in cancer aggressiveness exemplifying the relevance of its selective inhibition for cancer therapy.
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