Journal
CELL BIOCHEMISTRY AND FUNCTION
Volume 37, Issue 4, Pages 239-244Publisher
WILEY
DOI: 10.1002/cbf.3393
Keywords
FOXD3-AS1; breast cancer; invasion; lncRNA; migration
Categories
Funding
- National Natural Science Foundation of China [81572291]
- Natural Science Foundation of Zhejiang Province [LY17H160053, LGF18H160031, GF18H160071, LGF18H160032]
- Medical and Health Technology Projects of Zhejiang Province [2017187475]
- Science and Technology Project of Wenzhou [Y20170030]
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For women, breast cancer is the most commonly diagnosed cancer and the leading cause of women deaths due to cancer. In recent years, increasing long noncoding RNA (lncRNA) has been discovered to be related to tumorigenesis, progression, and prognosis. FOXD3-AS1 is a lncRNA and has been identified as a cancer-promoting gene in glioma. By analysing the FOXD3-AS1 expression in The Cancer Genome Atlas (TCGA) database, we found that FOXD3-AS1 has significantly high expression in breast cancer tumour comparing with the normal tissue. And patients with low FOXD3-AS1 expression had greater survival probability, smaller tumour size, and less distant metastasis. This leads us to peep inquisitively biological function of FOXD3-AS1 in breast cancer. Biological assays demonstrated that silenced FOXD3-AS1 impaired cell proliferation and inhibited cell migration and invasion in breast cancer cell lines (BT549, MDA-MB-231). These results suggest that FOXD3-AS1 could play a potential diagnostics or prognostic biomarker for patients with breast cancer. Significance of the study We demonstrated that lncRNA FOXD3-AS1 has significantly high expression in breast cancer cell lines comparing with the normal tissue. Besides, our findings suggested that lncRNA FOXD3-AS1 could play a potential diagnostics or prognostic biomarker for patients with breast cancer.
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