Journal
CELL
Volume 177, Issue 4, Pages 806-819Publisher
CELL PRESS
DOI: 10.1016/j.cell.2019.04.018
Keywords
-
Categories
Funding
- NIGMS [41402]
- Bioimaging Core Facility of WNLO-HUST
- Medical Research Council [MC_UU_12009, MC_UU_12010]
Ask authors/readers for more resources
Over the last several decades, an impressive array of advanced microscopic and analytical tools, such as single-particle tracking and nanoscopic fluorescence correlation spectroscopy, has been applied to characterize the lateral organization and mobility of components in the plasma membrane. Such analysis can tell researchers about the local dynamic composition and structure of membranes and is important for predicting the outcome of membrane-based reactions. However, owing to the unresolved complexity of the membrane and the structures peripheral to it, identification of the detailed molecular origin of the interactions that regulate the organization and mobility of the membrane has not proceeded quickly. This Perspective presents an overview of how cell-surface structure may give rise to the types of lateral mobility that are observed and some potentially fruitful future directions to elucidate the architecture of these structures in more molecular detail.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available