Journal
CELL
Volume 177, Issue 4, Pages 957-+Publisher
CELL PRESS
DOI: 10.1016/j.cell.2019.04.015
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Funding
- European Research Council under the European Union's Seventh Framework Programme (FP7/2007-2013)/ERC grant [742985]
- Marie Curie Fellowship [753138]
- Federation of European Biochemical Societies (FEBS) Long-Term Fellowship
- Marie Curie Actions (MSCA) [753138] Funding Source: Marie Curie Actions (MSCA)
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Patterning in plants relies on oriented cell divisions and acquisition of specific cell identities. Plants regularly endure wounds caused by abiotic or biotic environmental stimuli and have developed extraordinary abilities to restore their tissues after injuries. Here, we provide insight into a mechanism of restorative patterning that repairs tissues after wounding. Laser-assisted elimination of different cells in Arabidopsis root combined with live-imaging tracking during vertical growth allowed analysis of the regeneration processes in vivo. Specifically, the cells adjacent to the inner side of the injury re-activated their stem cell transcriptional programs. They accelerated their progression through cell cycle, coordinately changed the cell division orientation, and ultimately acquired de novo the correct cell fates to replace missing cells. These observations highlight existence of unknown intercellular positional signaling and demonstrate the capability of specified cells to re-acquire stem cell programs as a crucial part of the plant-specific mechanism of wound healing.
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