4.8 Editorial Material

Does Autophagy Promote Longevity? It Depends

Journal

CELL
Volume 177, Issue 2, Pages 221-222

Publisher

CELL PRESS
DOI: 10.1016/j.cell.2019.03.021

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Funding

  1. Howard Hughes Medical Institute Funding Source: Medline
  2. NIA NIH HHS [R01 AG045183] Funding Source: Medline
  3. NIDDK NIH HHS [DP1 DK113644] Funding Source: Medline
  4. NIEHS NIH HHS [T32 ES027801] Funding Source: Medline

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Zhou et al. challenge the well-known beneficial effect of autophagy in promoting longevity. Evidence presented demonstrate that autophagy induction coupled with increased mitochondrial permeability is detrimental to organismal health in both the nematode Caenorhabditis elegans and mammals.

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