Journal
CELL
Volume 177, Issue 5, Pages 1094-1107Publisher
CELL PRESS
DOI: 10.1016/j.cell.2019.04.024
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Funding
- NCI NIH HHS [R01 CA169291, R35 CA231620] Funding Source: Medline
- NIAID NIH HHS [R01 AI044828, R37 AI044828] Funding Source: Medline
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Active cell death, in its many forms, is a fundamental biological process. Studies over the past several decades have explored the functions and consequences of cellular demise and elucidated several of the key cell death pathways. Here, I pose five questions, or riddles, that might provide a guide to the next decade of cell death research. Focusing mainly on four types of active cell death (apoptosis, necroptosis, pyroptosis, and ferroptosis) mainly in mammals, this Perspective explores the possible research directions that might answer these riddles, or at least prompt new ones.
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