Journal
CELL
Volume 177, Issue 7, Pages 1858-+Publisher
CELL PRESS
DOI: 10.1016/j.cell.2019.04.027
Keywords
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Categories
Funding
- NIH [F31 MH116613, R01 NS091010A, R01 EY025349, R01 DC014690, U01 NS094342, P30EY022589]
- Pew Charitable Trusts
- David and Lucile Packard Foundation
- McKnight Foundation
- New York Stem Cell Foundation
- Kavli Institute for Brain and Mind
- NSF [1734940]
- Uehara Memorial Foundation Postdoctoral Fellowship
- ARCS Foundation
- San Diego Fellowship
- UCSD Q-Bio TG (NIH) [1T32GM127235-01]
- Directorate For Engineering
- Div Of Electrical, Commun & Cyber Sys [1734940] Funding Source: National Science Foundation
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Decision making is often driven by the subjective value of available options, a value which is formed through experience. To support this fundamental behavior, the brain must encode and maintain the subjective value. To investigate the area specificity and plasticity of value coding, we trained mice in a value-based decision task and imaged neural activity in 6 cortical areas with cellular resolution. History- and value-related signals were widespread across areas, but their strength and temporal patterns differed. In expert mice, the retrosplenial cortex (RSC) uniquely encoded history- and value-related signals with persistent population activity patterns across trials. This unique encoding of RSC emerged during task learning with a strong increase in more distant history signals. Acute inactivation of RSC selectively impaired the reward-history-based behavioral strategy. Our results indicate that RSC flexibly changes its history coding and persistently encodes value-related signals to support adaptive behaviors.
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