Journal
CARBOHYDRATE POLYMERS
Volume 212, Issue -, Pages 334-344Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.carbpol.2019.02.045
Keywords
Gold nanorod; Hydroxyethyl chitosan; Combined photothermal-chemotherapy; Breast cancer
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Funding
- Key Science and Technology Program of Shaanxi Province, China [2017SF-179, 2017SF-190]
- Foundation of First Affiliated Hospital of Xi'an Jiaotong University [2016MS-04]
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Chemo-photothermal combination therapy is a promising strategy for cancer treatment. In this study, to achieve the combined photothermal-chemotherapy of breast cancer, a pH-sensitive oxidized hyaluronic acid-decorated dihydroxyphenyl/hydrazide bifunctionalized hydroxyethyl chitosan (DHHC)-gold nanorod (GNR) conjugate was developed. DHHC was synthesized by successive dihydroxyphenylation and hydrazidation of hydroxyethyl chitosan through carbodiimide reaction and click chemistry, respectively. The conjugate was obtained by chemically bonding DHHC onto GNR via Au-catechol bonds. Doxorubicin (DOX) was loaded onto the conjugate via an acid-labile hydrazone linkage with a drug loading content of 5.1%. DOX-loaded conjugate displayed good stability in neutral aqueous solutions and exhibited pH-responsive drug release and surface charge reversal behaviors. In vitro biological studies indicated that the conjugate could be effectively internalized by breast cancer MCF-7 cells and synergistic therapeutic effects were demonstrated, suggesting its great potential in combined photothermal-chemotherapy of breast cancer.
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