Journal
CANCER LETTERS
Volume 458, Issue -, Pages 86-91Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2019.05.019
Keywords
Hepatocellular carcinoma; Tumor-associated macrophage; Targeted therapy; Immunotherapy
Categories
Funding
- state Key project for liver cancer [2018ZX10732202-001]
- National Research Program of China [2017YFA0505803, 2017YFC0908100]
- National Natural Science Foundation of China [81790633, 91729303, 81672860, 81702298, 81422032]
- National Natural Science Foundation of Shanghai [17ZR143800]
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Tumor-associated macrophage (TAM) plays a prominent role in inflammatory microenvironment which contributes to hepatocellular carcinoma (HCC) progress by presenting M1 and M2 polarization. HCC, which is highly associated with inflammation, always leads to poor prognosis for recurrence and metastasis. TAMs with M2 polarization induce cellular proliferation, angiogenesis, epithelial-mesenchymal transition (EMT) in HCC. Furthermore, it also interacts with other immune cell clusters which leads to the resistance in targeted therapy and immunotherapy. This article reviews studies on the role of TAM to affect HCC treatment and provides insight into the potential individualized precision monotherapy or combination therapy in HCC.
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