Journal
CANCER LETTERS
Volume 448, Issue -, Pages 52-60Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2019.02.007
Keywords
USP26; Snail; Deubiquitination; Epithelial-mesenchymal transition; ESCC
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Funding
- National Key R&D Program of China [2016YFC1302100]
- CAMS Innovation Fund for Medical Sciences [2016-12M-1-001]
- National Science Foundation of China [81773134]
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Snail is an important transcription factor of epithelial-mesenchymal transition (EMT) and related to poor prognosis and distant metastasis of tumor patients. Snail is a liable protein and degraded by ubiquitin-proteasome system. There are various E3 ligases mediating its degradation, but the deubiquitinating enzyme reversed Snail degradation is not fully understood. In this study, we screened a DUB library and found USP26 is a potent deubiquitinase mediating Snail stabilization. We also identified that USP26 is a booster of esophageal squamous cell carcinoma (ESCC) cell migration and invasion, and it is highly expressed in ESCC samples. Our observation demonstrates that USP26 is a novel deubiquitinating enzyme of Snail and it provides a potential target for the therapy of esophageal cancer metastasis.
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