Journal
CANCER LETTERS
Volume 458, Issue -, Pages 102-112Publisher
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2019.04.040
Keywords
CRISPR; mRNA; DNA; Gene editing; Drug delivery; Oncology; Nanotechnology
Categories
Funding
- Burroughs Wellcome Fund Career Award at the Scientific Interface (CAST), a US National Institutes of Health (NIH) Director's New Innovator Award [DP2 TR002776]
- American Cancer Society [129784-IRG-16-188-38-IRG]
- Abramson Cancer Center (ACC)-School of Engineering and Applied Sciences (SEAS) Discovery Grant [P30 CA016520]
- 2018 AACR-Bayer Innovation and Discovery Grant [18-80-44-MITC]
- NIH T32 multidisciplinary training grant [T32 HL007954]
- NSF
- NATIONAL CENTER FOR ADVANCING TRANSLATIONAL SCIENCES [DP2TR002776] Funding Source: NIH RePORTER
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Immunotherapy has recently emerged as a powerful tool for cancer treatment. Early clinical successes from cancer immunotherapy have led to a growing list of FDA approvals, and many new therapies are in clinical and preclinical development. Nucleic acid therapeutics, including DNA, mRNA, and genome editing systems, hold significant potential as a form of immunotherapy due to its robust use in cancer vaccination, adoptive T-cell therapy, and gene regulation. However, these therapeutics must overcome numerous delivery obstacles to be successful, including rapid in vivo degradation, poor uptake into target cells, required nuclear entry, and potential in vivo toxicity in healthy cells and tissues. Nanoparticle delivery systems have been engineered to overcome several of these barriers as a means to safely and effectively deliver nucleic acid therapeutics to immune cells. In this Review, we discuss the applications of nucleic acid therapeutics in cancer immunotherapy, and we detail how nanoparticle platforms have been designed to deliver mRNA, DNA, and genome editing systems to enhance the potency and safety of these therapeutics.
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