Journal
BRITISH JOURNAL OF ANAESTHESIA
Volume 123, Issue 2, Pages E424-E433Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.bja.2019.03.030
Keywords
causalgia; chronic pain; CRPS; reflex sympathetic dystrophy
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Complex regional pain syndrome (CRPS) is a life-altering condition that usually affects the extremities after a trauma or nerve injury. The physiologic changes that occur as a result of the inciting injury are complex, as the name of the syndrome implies. The pain and disability associated with CRPS often lead to psychological co-morbidities that create a vicious cycle of pain, isolation, and depression. We review recent developments in the understanding of CRPS and advancements in management of this syndrome. Further research in targeting specific mechanisms involved in the pathophysiology of CRPS should lead to prevention of this condition.
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