4.5 Review

3D Primary Hepatocyte Culture Systems for Analyses of Liver Diseases, Drug Metabolism, and Toxicity: Emerging Culture Paradigms and Applications

Related references

Note: Only part of the references are listed.
Article Multidisciplinary Sciences

AMP-activated protein kinase activation and NADPH oxidase inhibition by inorganic nitrate and nitrite prevent liver steatosis

Isabel Cordero-Herrera et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2019)

Article Biotechnology & Applied Microbiology

In vitro Liver Zonation of Primary Rat Hepatocytes

Lauren Tomlinson et al.

FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY (2019)

Review Pharmacology & Pharmacy

3D bioprinting of functional tissue models for personalized drug screening and in vitro disease modeling

Xuanyi Ma et al.

ADVANCED DRUG DELIVERY REVIEWS (2018)

Review Pharmacology & Pharmacy

Application of Microphysiological Systems to Enhance Safety Assessment in Drug Discovery

Lorna Ewart et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 58 (2018)

Review Pharmacology & Pharmacy

Physiologically Based Pharmacokinetic and Pharmacodynamic Analysis Enabled by Microfluidically Linked Organs-on-Chips

Rachelle Prantil-Baun et al.

ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 58 (2018)

Review Cell & Tissue Engineering

Organs-on-a-Chip: A Fast Track for Engineered Human Tissues in Drug Development

Kacey Ronaldson-Bouchard et al.

CELL STEM CELL (2018)

Review Gastroenterology & Hepatology

Translating scientific discovery: the need for preclinical models of nonalcoholic steatohepatitis

Abdul M. Oseini et al.

HEPATOLOGY INTERNATIONAL (2018)

Review Pharmacology & Pharmacy

Human-based systems: Mechanistic NASH modelling just around the corner?

Joost Boeckmans et al.

PHARMACOLOGICAL RESEARCH (2018)

Article Multidisciplinary Sciences

3D microfluidic liver cultures as a physiological preclinical tool for hepatitis B virus infection

A. M. Ortega-Prieto et al.

NATURE COMMUNICATIONS (2018)

Article Chemistry, Medicinal

HLA-A*33:03-Restricted Activation of Ticlopidine-Specific T-Cells from Human Donors

Toru Usui et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2018)

Article Cell & Tissue Engineering

Three-Dimensional Spheroid Primary Human Hepatocytes in Monoculture and Coculture with Nonparenchymal Cells

Audrey Baze et al.

TISSUE ENGINEERING PART C-METHODS (2018)

Article Multidisciplinary Sciences

Human hepatic 3D spheroids as a model for steatosis and insulin resistance

Mikael Kozyra et al.

SCIENTIFIC REPORTS (2018)

Review Engineering, Biomedical

3D bioprinting for biomedical devices and tissue engineering: A review of recent trends and advances

Soroosh Derakhshanfar et al.

BIOACTIVE MATERIALS (2018)

Article Gastroenterology & Hepatology

A Cell Culture Platform to Maintain Long-term Phenotype of Primary Human Hepatocytes and Endothelial Cells

Brenton R. Ware et al.

CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY (2018)

Article Cell & Tissue Engineering

Three-dimensional co-culture of human hepatocytes and mesenchymal stem cells: improved functionality in long-term bioreactor cultures

Sofia P. Rebelo et al.

JOURNAL OF TISSUE ENGINEERING AND REGENERATIVE MEDICINE (2017)

Article Medicine, Research & Experimental

Control of oxygen tension recapitulates zone-specific functions in human liver microphysiology systems

Felipe T. Lee-Montiel et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2017)

Article Gastroenterology & Hepatology

Three-dimensional perfused human in vitro model of nonalcoholic fatty liver disease

Tomasz Kostrzewski et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2017)

Article Pharmacology & Pharmacy

Worldwide Distribution of Cytochrome P450 Alleles: A Meta-analysis of Population-scale Sequencing Projects

Y. Zhou et al.

CLINICAL PHARMACOLOGY & THERAPEUTICS (2017)

Article Biochemistry & Molecular Biology

Small molecule absorption by PDMS in the context of drug response bioassays

B. J. van Meer et al.

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2017)

Article Pharmacology & Pharmacy

Quantitative Assessment of Population Variability in Hepatic Drug Metabolism Using a Perfused Three-Dimensional Human Liver Microphysiological Systems

N. Tsamandouras et al.

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2017)

Article Medicine, Research & Experimental

A human liver microphysiology platform for investigating physiology, drug safety, and disease models

Lawrence A. Vernetti et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2016)

Article Gastroenterology & Hepatology

The economic and clinical burden of nonalcoholic fatty liver disease in the United States and Europe

Zobair M. Younossi et al.

HEPATOLOGY (2016)

Article Gastroenterology & Hepatology

Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation

Volker M. Lauschke et al.

HEPATOLOGY (2016)

Review Biochemistry & Molecular Biology

The Importance of Patient-Specific Factors for Hepatic Drug Response and Toxicity

Volker M. Lauschke et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2016)

Review Biotechnology & Applied Microbiology

Bioprinting towards Physiologically Relevant Tissue Models for Pharmaceutics

Weijie Peng et al.

TRENDS IN BIOTECHNOLOGY (2016)

Review Materials Science, Biomaterials

3D Printed Tissue Models: Present and Future

Jinah Jang et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2016)

Review Materials Science, Biomaterials

3D Printed Tissue Models: Present and Future

Jinah Jang et al.

ACS BIOMATERIALS SCIENCE & ENGINEERING (2016)

Article Multidisciplinary Sciences

Hepatic 3D spheroid models for the detection and study of compounds with cholestatic liability

Delilah F. G. Hendriks et al.

SCIENTIFIC REPORTS (2016)

Article Pharmacology & Pharmacy

Prediction of Drug Clearance and Drug-Drug Interactions in Microscale Cultures of Human Hepatocytes

Christine Lin et al.

DRUG METABOLISM AND DISPOSITION (2016)

Article Medicine, Research & Experimental

Development of an in vitro human liver system for interrogating nonalcoholic steatohepatitis

Ryan E. Feaver et al.

JCI INSIGHT (2016)

Article Engineering, Electrical & Electronic

Reaction injection molding and direct covalent bonding of OSTE plus polymer microfluidic devices

N. Sandstrom et al.

JOURNAL OF MICROMECHANICS AND MICROENGINEERING (2015)

Article Chemistry, Multidisciplinary

Substrate stiffness regulates primary hepatocyte functions

Vaishaali Natarajan et al.

RSC ADVANCES (2015)

Review Biotechnology & Applied Microbiology

Pluripotent stem cell-derived hepatocyte-like cells

R. E. Schwartz et al.

BIOTECHNOLOGY ADVANCES (2014)

Article Pharmacology & Pharmacy

Evaluation of Human Hepatocytes Cultured by Three-dimensional Spheroid Systems for Drug Metabolism

Takako Ohkura et al.

DRUG METABOLISM AND PHARMACOKINETICS (2014)

Review Medicine, Research & Experimental

In vitro platforms for evaluating liver toxicity

Shyam Sundhar Bale et al.

EXPERIMENTAL BIOLOGY AND MEDICINE (2014)

Article Polymer Science

Functional Off-Stoichiometry Thiol-ene-epoxy Thermosets Featuring Temporally Controlled Curing Stages via an UV/UV Dual Cure Process

Carl Fredrik Carlborg et al.

JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY (2014)

Article Biochemical Research Methods

Dynamic interplay of flow and collagen stabilizes primary hepatocytes culture in a microfluidic platform

Manjunath Hegde et al.

LAB ON A CHIP (2014)

Article Biotechnology & Applied Microbiology

Lessons learned from the fate of AstraZeneca's drug pipeline: a five-dimensional framework

David Cook et al.

NATURE REVIEWS DRUG DISCOVERY (2014)

Review Medicine, General & Internal

Drug-Induced Liver Injury

Michael D. Leise et al.

MAYO CLINIC PROCEEDINGS (2014)

Article Multidisciplinary Sciences

Maturation of Induced Pluripotent Stem Cell Derived Hepatocytes by 3D-Culture

Richard L. Gieseck et al.

PLOS ONE (2014)

Article Toxicology

Multi-cell type human liver microtissues for hepatotoxicity testing

S. Messner et al.

ARCHIVES OF TOXICOLOGY (2013)

Article Engineering, Biomedical

3D spheroid culture of hESC/hiPSC-derived hepatocyte-like cells for drug toxicity testing

Kazuo Takayama et al.

BIOMATERIALS (2013)

Article Cell & Tissue Engineering

Developing High-Fidelity Hepatotoxicity Models From Pluripotent Stem Cells

Claire N. Medine et al.

STEM CELLS TRANSLATIONAL MEDICINE (2013)

Review Toxicology

In vitro models for liver toxicity testing

Valerie Y. Soldatow et al.

TOXICOLOGY RESEARCH (2013)

Article Chemistry, Medicinal

Preclinical Strategy to Reduce Clinical Hepatotoxicity Using in Vitro Bioactivation Data for >200 Compounds

Melanie Z. Sakatis et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2012)

Article Gastroenterology & Hepatology

Human liver cell spheroids in extended perfusion bioreactor culture for repeated-dose drug testing

Rui M. Tostoes et al.

HEPATOLOGY (2012)

Article Pharmacology & Pharmacy

HepaRG human hepatic cell line utility as a surrogate for primary human hepatocytes in drug metabolism assessment in vitro

Marc Luebberstedt et al.

JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS (2011)

Article Pharmacology & Pharmacy

Assessment of a Micropatterned Hepatocyte Coculture System to Generate Major Human Excretory and Circulating Drug Metabolites

Wendy WeiWei Wang et al.

DRUG METABOLISM AND DISPOSITION (2010)

Article Biochemical Research Methods

Perfused multiwell plate for 3D liver tissue engineering

Karel Domansky et al.

LAB ON A CHIP (2010)

Article Cell & Tissue Engineering

Photocrosslinkable Hyaluronan-Gelatin Hydrogels for Two-Step Bioprinting

Aleksander Skardal et al.

TISSUE ENGINEERING PART A (2010)

Article Chemistry, Medicinal

Predicting Circulating Human Metabolites: How Good Are We?

Shelby Anderson et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2009)

Article Chemistry, Medicinal

Assessment of Three Human in Vitro Systems in the Generation of Major Human Excretory and Circulating Metabolites

Deepak Dalvie et al.

CHEMICAL RESEARCH IN TOXICOLOGY (2009)

Review Biochemical Research Methods

Biological implications of polydimethylsiloxane-based microfluidic cell culture

Keil J. Regehr et al.

LAB ON A CHIP (2009)

Article Biochemistry & Molecular Biology

T-cadherin modulates hepatocyte functions in vitro

Salman R. Khetani et al.

FASEB JOURNAL (2008)

Article Multidisciplinary Sciences

Bioactive Contaminants Leach from Disposable Laboratory Plasticware

G. Reid McDonald et al.

SCIENCE (2008)

Article Toxicology

Cellular imaging predictions of clinical drug-induced liver injury

Jinghai J. Xu et al.

TOXICOLOGICAL SCIENCES (2008)

Article Biotechnology & Applied Microbiology

Microscale culture of human liver cells for drug development

Salman R. Khetani et al.

NATURE BIOTECHNOLOGY (2008)

Article Biochemical Research Methods

PDMS absorption of small molecules and consequences in microfluidic applications

Michael W. Toepke et al.

LAB ON A CHIP (2006)

Review Biochemistry & Molecular Biology

Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction

Marcella Martignoni et al.

EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2006)

Article Toxicology

In vitro zonation and toxicity in a hepatocyte bioreactor

JW Allen et al.

TOXICOLOGICAL SCIENCES (2005)

Article Biotechnology & Applied Microbiology

A microfabricated array bioreactor for perfused 3D liver culture

MJ Powers et al.

BIOTECHNOLOGY AND BIOENGINEERING (2002)