Journal
BIOORGANIC CHEMISTRY
Volume 86, Issue -, Pages 679-685Publisher
ACADEMIC PRESS INC ELSEVIER SCIENCE
DOI: 10.1016/j.bioorg.2019.01.058
Keywords
Sophora flavescens; Biflavonoids; Sophobiflavonoids A-H; PTP1B inhibitory activity
Funding
- Fundamental Research Funds for the Central Universities [3332018085]
- State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University [FAMP201706K]
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In the course of studying the components from the roots of Sophora flavescens, eight new unusual biflavonoids consisting of a flavanone fused with a dihydrochalcone skeleton were isolated. These new chemical structures were elucidated by means of UV, IR, HRESIMS, NMR and ECD spectroscopic data and a comparison of experimental ECD spectra with calculated ECD spectra. Some compounds were subjected to an antidiabetic bioassay on human recombinant PTP1B inhibition, and showed strong inhibitory activity.
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