Journal
BIOMATERIALS
Volume 214, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2019.119223
Keywords
Nanozyme; Metal-organic framework; Enzyme mimics; Microwave; Cancer therapy
Funding
- National Key RD Program [2018YFC0115503, 2018YFC0115500]
- National Natural Science Foundation of China [81630053, 61671435, 61571426]
- CAS-DOE program [GJHZ1705]
- Beijing Natural Science Foundation [4161003]
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Nanozymes with excellent enzyme-mimicking catalytic property are playing an increasingly significant role in tumor diagnosis and therapy. Fe-metal organic framework nanoparticles (MIL-101(Fe) NPs) are prepared as nanozymes to generate reactive oxygen species (ROS) and induce cancer cell death by catalyzing endogenous substances in tumor microenvironment. Abundant stimuli-responsive hydroxyl radicals (center dot OH) are accelerated to generate in the presence of microwave irradiation, realizing microwave enhancing dynamic therapy (MEDT). Moreover, MIL-101(Fe) NPs possess biodegradability and bioresponsibility, which exhibit favourable properties of metabolism and non-toxic accumulation comparing with inorganic nanozymes. Fluorescent gold nanodusters (BSA-Au NCs) are rapidly coupled with the surface of MIL-101(Fe) NPs to obtain MIL-101(Fe)@BSA-AuNCs NPs. MIL-101(Fe)@BSA-AuNCs NPs with magnetic resonance imaging (MRI) and fluorescent imaging (FI) not only image accurately for the site of tumor, but also monitor dynamic distribution process of MIL-101(Fe) in vivo. The signal intensity of FI and MRI reaches maximum at 1 h in the liver and 5 h in the tumor. Ionic liquid (IL) is also loaded into MIL-101(Fe)@BSA-AuNCs NPs as microwave sensitive reagents for microwave thermal therapy (MTT). This work synthesizes the nanozymes that possess degradability, microwave sensitivity and dual-mode imaging to achieve the combination of MTT and MEDT against tumor. Experiment result in vivo confirms that the kill rate of tumor is up to 96.65%, showing an outstanding anti-tumor efficacy.
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