Journal
BIOCHEMICAL JOURNAL
Volume 476, Issue -, Pages 1083-1104Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BCJ20180440
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Funding
- NIH [DP2MH107055, R01GM127408, T32HG000046, T32 HD083185]
- Searle Scholars Program [15-SSP-102]
- March of Dimes Foundation [1-FY-15-344]
- Linda Pechenik Montague Investigator Award
- Charles E. Kaufman Foundation [KA2016-85223]
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Long noncoding RNAs (lncRNAs) are transcripts that do not code for proteins, but nevertheless exert regulatory effects on various biochemical pathways, in part via interactions with proteins, DNA, and other RNAs. LncRNAs are thought to regulate transcription and other biological processes by acting, for example, as guides that target proteins to chromatin, scaffolds that facilitate protein-protein interactions and complex formation, and orchestrators of phase-separated compartments. The study of lncRNAs has reached an exciting time, as recent advances in experimental and computational methods allow for genome-wide interrogation of biochemical and biological mechanisms of these enigmatic transcripts. A better appreciation for the biochemical versatility of lncRNAs has allowed us to begin closing gaps in our knowledge of how they act in diverse cellular and organismal contexts, including development and disease.
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