Journal
AUTOPHAGY
Volume 16, Issue 1, Pages 3-17Publisher
TAYLOR & FRANCIS INC
DOI: 10.1080/15548627.2019.1603547
Keywords
Immune cells; inflammatory bowel diseases; inflammatory cytokines; mitophagy; primary biliary cirrhosis; systemic lupus erythematosus
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Mitophagy is a vital form of autophagy for selective removal of dysfunctional or redundant mitochondria. Accumulating evidence implicates elimination of dysfunctional mitochondria as a powerful means employed by autophagy to keep the immune system in check. The process of mitophagy may restrict inflammatory cytokine secretion and directly regulate mitochondrial antigen presentation and immune cell homeostasis. In this review, we describe distinctive pathways of mammalian mitophagy and highlight recent advances relevant to its function in immunity. In addition, we further discuss the direct and indirect evidence linking mitophagy to inflammation and autoimmunity underlying the pathogenesis of autoimmune diseases including inflammatory bowel diseases (IBD), systemic lupus erythematosus (SLE) and primary biliary cirrhosis (PBC).
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