Journal
AQUATIC TOXICOLOGY
Volume 209, Issue -, Pages 132-141Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.aquatox.2019.02.004
Keywords
TDCIPP; Parental transfer; Growth inhibition; Hypothalamic-pituitary-thyroid axis; Growth hormone/insulin-like growth factor axis; Offspring
Categories
Funding
- National Natural Science Foundation of China [21507039, 51778268]
- Province Department of Education Thirteen Five scientific and technological research projects of Jilin, China [JJKH2O192.8765KJ, JJKH20191027KJ]
- Jilin Province Science and Technology Department outstanding young talent fund project [20170520072JH]
- Department of Science & Technology of Jilin Province [20180623042TC]
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Tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) is a re-emerging environmental contaminant used as a suitable substitute for brominated flame retardants. The objective of this study was to evaluate the effects of TDCIPP on thyroid disruption and growth inhibition in zebrafish (Danio rerio) offspring after chronic parental exposure, and to examine the possible molecular mechanisms involved. When adult zebrafish (4 months old) were exposed to 5.66, 25.55, or 92.8 mu g TDCIPP/L for 90 days, bioconcentration of TDCIPP and its metabolic product [bis(1,3-dichloro-2-propyl) phosphate, BDCIPP] was observed in 7-day postfertilization (dpf) F1 larvae, which suggests the transfer of this compound from adult fish to their offspring. Our results demonstrated that parental exposure to TDCIPP induced thyroid disruption in the offspring, demonstrated by significantly decreased thyroxine (T4) and increased 3,5,3'-triiodothyronine (T3) levels, and disruption of the transcription of several genes and expression of proteins involved in the hypothalamic-pituitary-thyroid (HPT) axis in F1 larvae. Parental exposure to TDCIPP resulted in developmental abnormalities in offspring; the smaller body length that was recorded might be partly the result of the perturbation of the HPT axis. In addition, the results revealed that growth inhibition also resulted from the downregulation of the transcription of genes and expression of proteins involved in the growth hormone/insulin-like growth factor (GH/IGF) axis. Our study provides a new set of evidence showing that parental exposure to TDCIPP can induce thyroid disruption and inhibition of growth in offspring, and that perturbation of the HPT axis and GH/IGF axis contribute to these adverse effects.
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