Journal
BIOLOGY LETTERS
Volume 11, Issue 2, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rsbl.2015.0010
Keywords
X chromosome; non-synonymous substitutions; synonymous substitutions; fast-X; hemizygosity; gene expression
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Funding
- Agence Nationale de la Recherche [ANR-14-CE02-0002-01, ANR-10-BINF-01-02]
- Agence Nationale de la Recherche (ANR) [ANR-14-CE02-0002] Funding Source: Agence Nationale de la Recherche (ANR)
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The higher rate of non-synonymous over synonymous substitutions (dN/dS) of the X chromosome compared with autosomes is often interpreted as a consequence of X hemizygosity. However, other factors, such as gene expression, are also known to vary between X and autosomes. Analysing 4800 orthologues in six mammals, we found that gene expression levels, associated with GC content, fully account for the variation in dN/dS between X and autosomes with no detectable effect of hemizygosity. We also report an extensive variance in dN/dS and gene expression between autosomes.
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