Journal
BIOLOGY LETTERS
Volume 11, Issue 4, Pages -Publisher
ROYAL SOC
DOI: 10.1098/rsbl.2014.1031
Keywords
selection; non-synonymous/synonymous ratio; substitution; influenza; chloroplast; adaptive evolution
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Funding
- BBSRC (UK) [BB/J009709/1]
- Biotechnology and Biological Sciences Research Council [BB/J009709/1] Funding Source: researchfish
- BBSRC [BB/J009709/1] Funding Source: UKRI
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First principles of population genetics are used to obtain formulae relating the non-synonymous to synonymous substitution rate ratio to the selection coefficients acting at codon sites in protein-coding genes. Two theoretical cases are discussed and two examples from real data (a chloroplast gene and a virus polymerase) are given. The formulae give much insight into the dynamics of non-synonymous substitutions and may inform the development of methods to detect adaptive evolution.
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