Journal
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
Volume 189, Issue 3, Pages 729-744Publisher
SPRINGER
DOI: 10.1007/s12010-019-03027-9
Keywords
Vina-ginsenoside R7; UVB; Photoaging; NF-kappa B; Inflammation
Funding
- SBA, Seoul Business Agency, Republic of Korea [CI160067]
- Snow White Factory Co., Ltd.
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Vina-ginsenoside R7 (R7) has been exhibited to engage in multiple pharmacological activities, such as antioxidant and anti-inflammatory activities. However, no photoaging-related studies have been performed on R7. Research is being conducted with the aim of assessing whether treatment with R7 has a protective effect on UVB-induced photoaging skin. Our results show that UVB exposure directly reduces matrix metalloproteinase (MMP) secretion through R7 by restraining the AP-1/MAPK pathway and blocks extracellular matrix (ECM) expression degradation. In addition, R7 improves the expression of transforming growth factor beta 1 (TGF-beta 1), and type I procollagen also facilitates the synthesis of collagen by the TGF-beta /Smad signal transduction pathway. Finally, R7 valid blocks nuclear factor-kappa B (NF-kappa B) activation and enhances antioxidative stress capacity through activated nuclear factor (erythroid derived 2)-like 2 (Nrf2). In particular, the application of R7 restrains pro-inflammatory cytokines (TNF-alpha, IL-6, iNOS), which trigger ECM, degrade enzyme production, and suppress vascular endothelial growth factor (VEGF) secretion. In conclusion, R7 may constitute a promising cosmetic ingredient that can protect against skin photodamage resulting from detrimental UVB irradiation.
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