Journal
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
Volume 63, Issue 6, Pages -Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/AAC.00159-19
Keywords
Mycobacterium tuberculosis; genotyping; intrinsic antibiotic resistance
Categories
Funding
- Wellcome Trust [201344/Z/16/Z]
- German Center for Infection Research
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy [EXC 22167-390884018]
- Leibniz Science Campus EvoLUNG (Evolutionary Medicine of the Lung)
- Swiss National Science Foundation [310030_166687, IZRJZ3_164171, IZLSZ3_170834, CRSII5_177163]
- European Research Council [309540-EVODRTB]
- SystemsX.ch
- Wellcome Trust [201344/Z/16/Z] Funding Source: Wellcome Trust
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Using 894 phylogenetically diverse genomes of the Mycobacterium tuberculosis complex (MTBC), we simulated in silico the ability of the Hain Lifescience GenoType MTBC assay to differentiate the causative agents of tuberculosis. Here, we propose a revised interpretation of this assay to reflect its strengths (e.g., it can distinguish some strains of Mycobacterium canettii and variants of Mycobacterium bovis that are not intrinsically resistant to pyrazinamide) and limitations (e.g., Mycobacterium orygis cannot be differentiated from Mycobacterium africanum).
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