Journal
ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Volume 1450, Issue 1, Pages 5-14Publisher
WILEY
DOI: 10.1111/nyas.14090
Keywords
hemoglobin; thresholds; anemia; public health; clinical significance; technical meeting
Categories
Funding
- Bill & Melinda Gates Foundation, USA Funding Source: Medline
- Bill and Melinda Gates Foundation Funding Source: Medline
- International Micronutrient Malnutrition Prevention and Control Programme (IMMPaCt) at the Centers for Disease Control and Prevention (CDC), USA Funding Source: Medline
- United States Agency for International Development Funding Source: Medline
- United States Agency for International Development (USAID), USA Funding Source: Medline
- World Health Organization [001] Funding Source: Medline
- Evidence and Programme Guidance Unit, Department of Nutrition for Health and Development of the World Health Organization (WHO), Geneva, Switzerland Funding Source: Medline
- International Micronutrient Malnutrition Prevention and Control Programme (IMMPaCt) Funding Source: Medline
- CDC HHS Funding Source: Medline
- Intramural CDC HHS [CC999999] Funding Source: Medline
- Evidence and Programme Guidance Unit, Department of Nutrition for Health and Development Funding Source: Medline
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Anemia is an important public health problem that negatively affects health of individuals and economic potential of populations. An accurate case definition is critical for understanding burden and epidemiology of anemia, for planning public health interventions, and for clinical investigation and treatment of patients. The current threshold hemoglobin concentrations for diagnosis of anemia were proposed in 1968 and based on studies predominantly of Caucasian adult populations in Europe and North America. The World Health Organization is undertaking a project to review global guidelines for anemia. We describe the process of obtaining input from technical experts, researchers, blood bank experts, policy makers, and program implementers to identify key information or knowledge gaps for anemia diagnosis. From this scoping exercise, six priority areas were identified on diverse topics related to the use and interpretation of hemoglobin concentrations to diagnose anemia in individuals and populations. A call for authors was conducted to produce background, review, and research papers across priority topics. This paper summarizes the first technical meeting, which included commissioned papers as well as case studies, describes key data gaps identified, and describes the next steps in the guideline development process to assess available evidence and define knowledge gaps to improve anemia characterization.
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