Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 26, Pages 8829-8833Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201903801
Keywords
difluoroacetic acid; hydrodifluoromethylation; hypervalent iodine compounds; photochemistry; radicals
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Funding
- European Union's Horizon 2020 research and innovation programme under the Marie Skodowska-Curie grant [721902]
- Marie Curie Actions (MSCA) [721902] Funding Source: Marie Curie Actions (MSCA)
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A facile method for the regioselective hydrodifluoromethylation of alkenes is reported using difluoroacetic acid and phenyliodine(III) diacetate in tetrahydrofuran under visible-light activation. This metal-free approach stands out as it uses inexpensive reagents, does not require a photocatalyst, and displays broad functional group tolerance. The procedure is also operationally simple and scalable, and provides access in one step to high-value building blocks for application in medicinal chemistry.
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