Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 23, Pages 7687-7691Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201902171
Keywords
heterogeneous catalysis; hydroamination; indoles; metal-organic frameworks; zinc
Categories
Funding
- Strategic Priority Research Program of the Chinese Academy of Sciences [XDB20000000]
- Key Research Program of Frontier Sciences, Chinese Academy of Sciences [QYZDB-SSW-SLH019]
- National Natural Science Foundation of China [21771177, 51603206]
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The exploitation of new and active earth-abundant metal catalysts is critical for sustainable chemical production. Herein, we demonstrate the design of highly efficient, robust, and reusable Zn-II-bipyridine-based metal-organic framework (MOF) catalysts for the intramolecular hydroamination of o-alkynylanilines to indoles. Under similar conditions homogeneous catalytic systems mainly provide hydrolysate. Our results prove that MOFs support unique internal environments that can affect the direction of chemical reactions. The Zn-II-catalyzed hydroamination reaction can be conducted without additional ligands, base, or acid, and is thus a very clean reaction system with regard to its environmental impact.
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