Journal
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
Volume 58, Issue 25, Pages 8426-8431Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.201902537
Keywords
bioimaging; boronic acid; fluorescent probes; Gram-positive bacteria; structure-activity relationships
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Funding
- Institute for Basic Science (IBS) [IBS-R007-A1]
- POSTECH (Pohang University of Science and Technology)
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The rapid and sensitive classification of bacteria is the first step of bacterial community research and the treatment of infection. Herein, a fluorescent probe BacGO is presented, which shows the best universal selectivity for Gram-positive bacteria among known probes with a minimum staining procedure for sample detection and enrichment of the live bacteria. BacGO could also be used to assess of the Gram status in the bacterial community from wastewater sludge. Furthermore, BacGO could sensitively and selectively detect a Gram-positive bacterial infection, not only invitro but also using an invivo keratitis mouse model. BacGO provides an unprecedented research tool for the study of dynamic bacterial communities and for clinical application.
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