Journal
ANESTHESIA AND ANALGESIA
Volume 128, Issue 4, Pages 781-788Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1213/ANE.0000000000004053
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Funding
- National Institutes of Health [R01 AG057525, R21 AG055877-01A1]
- Duke Institute for Brain Sciences Incubator Award
- Duke Anesthesiology
- NATIONAL INSTITUTE ON AGING [R21AG055877, R01AG057525] Funding Source: NIH RePORTER
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Neuroinflammation has become a key hallmark of neurological complications including perioperative pathologies such as postoperative delirium and longer-lasting postoperative cognitive dysfunction. Dysregulated inflammation and neuronal injury are emerging from clinical studies as key features of perioperative neurocognitive disorders. These findings are paralleled by a growing body of preclinical investigations aimed at better understanding how surgery and anesthesia affect the central nervous system and possibly contribute to cognitive decline. Herein, we review the role of postoperative neuroinflammation and underlying mechanisms in immune-to-brain signaling after peripheral surgery.
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