Journal
AMINO ACIDS
Volume 52, Issue 2, Pages 301-311Publisher
SPRINGER WIEN
DOI: 10.1007/s00726-019-02721-6
Keywords
Spermidine; Carbon quantum dots; Nano-hybrid; Cell tracker; Magnetic nanoparticle
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Funding
- Ministerstvo Školství, Mládeže a Tělovýchovy [LO1204] Funding Source: Medline
- Italian Institutional Ministry [DOR1872491] Funding Source: Medline
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The combination of different nanomaterials has been investigated during the past few decades and represents an exciting challenge for the unexpected emerging properties of the resulting nano-hybrids. Spermidine (Spd), a biogenic polyamine, has emerged as a useful functional monomer for the development of carbon quantum dots (CQDs). Herein, an electrostatically stabilized ternary hybrid, constituted of iron oxide-DNA (the core) and spermidine carbon quantum dots (CQD(Spds), the shell), was self-assembled and fully characterized. The as-obtained nano-hybrid was tested on HeLa cells to evaluate its biocompatibility as well as cellular uptake. Most importantly, besides being endowed by the magnetic features of the core, it displayed drastically enhanced fluorescence properties in comparison with parent CQD(Spds) and it is efficiently internalized by HeLa cells. This novel ternary nano-hybrid with multifaceted properties, ranging from fluorescence to superparamagnetism, represents an interesting option for cell tracking.
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