Journal
AMERICAN JOURNAL OF TRANSPLANTATION
Volume 19, Issue 9, Pages 2583-2593Publisher
WILEY
DOI: 10.1111/ajt.15393
Keywords
donors and donation; deceased; donors and donation; donor-derived infections; ethics and public policy; infection and infectious agents - viral; infectious disease; mathematical model; organ procurement and allocation; organ transplantation in general
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Funding
- Intramural CDC HHS [CC999999] Funding Source: Medline
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To reduce the risk of HIV, hepatitis B virus (HBV), and hepatitis C virus (HCV) transmission through organ transplantation, donors are universally screened for these infections by nucleic acid tests (NAT). Deceased organ donors are classified as increased risk if they engaged in specific behaviors during the 12 months before death. We developed a model to estimate the risk of undetected infection for HIV, HBV, and HCV among NAT-negative donors specific to the type and timing of donors' potential risk behavior to guide revisions to the 12-month timeline. Model parameters were estimated, including risk of disease acquisition for increased risk groups, number of virions that multiply to establish infection, virus doubling time, and limit of detection by NAT. Monte Carlo simulation was performed. The risk of undetected infection was HIV after 14 days, for HBV after 35 days, and for HCV after 7 days from the time of most recent potential exposure to the day of a negative NAT. The period during which reported donor risk behaviors result in an increased risk designation can be safely shortened.
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