Journal
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
Volume 317, Issue 2, Pages H213-H225Publisher
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpheart.00065.2019
Keywords
immunomodulation; inflammation; mesenchymal stem cell; myocardial infarction; myocardial repair
Funding
- Canadian Institutes of Health Research Grant [MOP142265]
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Ischemic heart disease is a growing worldwide epidemic. Improvements in medical and surgical therapies have reduced early mortality after acute myocardial infarction and increased the number of patients living with chronic heart failure. The irreversible loss of functional cardiomyocytes puts these patients at significant risk of ongoing morbidity and mortality after their index event. Recent evidence suggests that inflammation is a key mediator of postinfarction adverse remodeling in the heart. In this review, we discuss the cardioprotective and deleterious effects of inflammation and its mediators during acute myocardial infarction. We also explore the role of mesenchymal stem cell therapy to limit secondary injury and promote myocardial healing after myocardial infarction.
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