Journal
AGING-US
Volume 11, Issue 9, Pages 2889-2897Publisher
IMPACT JOURNALS LLC
DOI: 10.18632/aging.101961
Keywords
cellular senescence; c-Met; Akt; Stat3; human dermal and pulmonary fibroblasts
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Funding
- Fund in Memory of Dr. Amir Abramovich
- Israel-America Foundation
- Israel Science Foundation [ISF 700/16]
- Concern Foundation [7895]
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Here, we reported for the first time an increased expression of c-Met protein in primary cultures of human dermal and pulmonary fibroblasts of late passages. This suggests that c-Met could serve as an early marker of cellular senescence (CS). The levels of c-Met-related signaling proteins phospho-Akt and Stat3 were also increased in (pre)senescent fibroblasts. Considering the anti-apoptotic activity of Akt and the involvement of Stat3 in mediating the effects of proinflammatory cytokines, the findings of this study indicate that c-Met could contribute through its downstream targets or partners to at least two major phenotypical features of CS - resistance to apoptosis and senescence-associated secretory phenotype.
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