Journal
ADVANCED SYNTHESIS & CATALYSIS
Volume 361, Issue 16, Pages 3662-3682Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201900532
Keywords
C-H functionalization; cobalt; copper; homogeneous catalysis; iron; nickel
Categories
Funding
- Royal Society [UF140161, RG150444, RGF\ EA\ 180031]
- EPSRC
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Directed C(sp(3))-H functionalisation has made enormous progress in recent years, but has largely been restricted to catalysis using noble metals, particularly palladium. However, since 2013, there have been prominent advances that exploit the reactivity of abundant first row transition metals for a multitude of new bond formations. The use of base metal catalysis for C-H functionalisation can provide huge advantages in terms of cost and sustainability compared to methods using noble metals. This review covers all examples, to the end 2018, of auxiliary-assisted, base metal-catalysed C(sp(3))-H functionalisation reactions. Successful examples are reported for Fe, Co, Ni and Cu catalysis with monodentate or bidentate directing groups for C-N, C-O, C-S and C-C bond forming reactions. This review aims to highlight the current state of this field and potential for expansion and so scope and limitations are highlighted. Notably, examples to date have required sterically activated alpha-disubstituted substrates, particularly propanamide derivatives with bidentate directing groups, such as 8-aminoquinoline amides. Monodentate quinoline and thioamide directing groups have also been used with Co catalysis for C-N and C-C bond formations. Mechanistic details are provided to outline the nature of the proposed organometallic intermediates and potential reaction pathways. We hope this review will stimulate further developments in this growing and important field.
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