4.7 Article

Lithium-Free Synthesis of Sodium 2,2,6,6-Tetramethylpiperidide and Its Synthetic Applications

Journal

ADVANCED SYNTHESIS & CATALYSIS
Volume 361, Issue 13, Pages 3120-3123

Publisher

WILEY-V C H VERLAG GMBH
DOI: 10.1002/adsc.201900215

Keywords

Sodium; 2,2,6,6-tetramethylpiperidine; Bronsted base; deprotonation

Funding

  1. KOBELCO ECO-Solutions CO., Ltd.
  2. Okayama University

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Lithium-free synthetic methods for sodium 2,2,6,6-tetramethylpiperide (NaTMP) have been developed using sodium dispersion as a sole sodium source. The prepared NaTMP was used as a Bronsted base, that exhibited some differences in reactivities from LiTMP.

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