Journal
ADVANCED MATERIALS
Volume 31, Issue 28, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adma.201901580
Keywords
controllable dissolution; fast degradation; sealants; Tetra-PEG hydrogels; visceral hemostasis
Categories
Funding
- National Natural Science Foundation of China [21725403, 21674120, 81630056]
- PLA Logistics Fund Surface Project [CWS14C066]
- National Defense Innovation Engineering Project [17-163-12-ZT-003-015-01]
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Medical sealant devices for in vivo hemostasis are far from satisfactory in the aged society. A major challenge is effective integration of quick hemorrhage control of the increased anticoagulated patients, high safety, and facile accessibility. Here, a well-defined ammonolysis-based Tetra-PEG hydrogel sealant is developed with rapid gelation speed, strong tissue adhesion, and high mechanical strength. Introduction of cyclized succinyl ester groups into a hydrogel matrix endows the sealant with fast degradable and controllably dissolvable properties. The hydrogel possesses outstanding hemostatic capabilities even under the anticoagulated conditions while displaying excellent biocompatibility and feasibility. These results reveal that the optimized hydrogel may be a facile, effective, and safe sealant for hemorrhage control in vivo.
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