Journal
ADVANCED FUNCTIONAL MATERIALS
Volume 29, Issue 22, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/adfm.201900372
Keywords
mesenchymal stem cells; nanotopography; neuron-like differentiation; piezoelectricity; polyvinylidene fluoride
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Funding
- Nature Science Foundation of Beijing [2172058]
- National Natural Science Foundation of China [81471784]
- Youth Innovation Promotion Association of the Chinese Academy of Sciences [2015023]
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The biophysical characteristics of the extracellular matrix, such as nanotopography and bioelectricity, have a profound influence on cell proliferation, adhesion, differentiation, etc. Recognition of the function of a certain biophysical cue and fabrication of biomaterial scaffolds with specific properties would have important implications and significant applications in tissue engineering. Herein, nanotopographic and piezoelectric biomaterials are fabricated and the combination effect of and individual contribution to proliferation, adhesion, and neuron-like differentiation of rat bone marrow-derived mesenchymal stem cells (rbMSCs) are clarified via nanotopography and piezoelectricity. Piezoelectric polyvinylidene fluoride with nanostripe array structures is fabricated, which can generate a surface piezoelectric potential up to millivolt by cell movement and traction. The results reveal a more favorable effect on neuron-like differentiation of rbMSCs from the combination of piezoelectricity and nanotopography rather than nanotopography alone, whereas nanotopography can increase cellular adhesion. This research provides a new insight into designing biomaterials for the potential application in neural tissue engineering.
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