Journal
ACTA MICROBIOLOGICA ET IMMUNOLOGICA HUNGARICA
Volume 66, Issue 3, Pages 387-398Publisher
AKADEMIAI KIADO ZRT
DOI: 10.1556/030.66.2019.015
Keywords
Staphylococcus aureus; erm genes; MRSA; clindamycin; Iran
Categories
Funding
- Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran [91126]
- Tropical and Infectious Diseases Research Center of the University [91126]
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The increasing resistance to macrolide, lincosamide, and streptogramin B agents among methicillin-resistant Staphylococcus aureus (MRSA) is a worldwide problem for the health community. This study aimed to investigate the prevalence of ermA, ermB, ermC, and msrA in MRSA strains isolated from burn patients in Ahvaz, southwest of Iran. A total of 76 isolates of S. aureus were collected from January to May 2017 from Taleghani Burn Hospital in Ahvaz. Among 76 S. aureus strains collected, 60 (78.9%) isolates were MRSA. The antimicrobial susceptibility testing for MRSA showed extreme high resistance rate to clarithromycin (100%) and azithromycin (100%), followed by erythromycin (98.3%). The PCR assay revealed that the frequency rates of msrA, ermA, and ermC genes were 23 (38.3%), 28 (46.7%), and 22 (36.7%), respectively. In addition, none of the MRSA isolates had the ermB gene. Because of the high prevalence of macrolide and lincosamide resistance found in MRSA isolates from infections of burn patients in Ahvaz, southwest of Iran, it is recommended that local periodic survey be performed for controlling the dissemination of antimicrobial resistance.
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