Minimal effect of walking before dinner on glycemic responses in type 2 diabetes: outcomes from the multi-site E-PAraDiGM study

AimTo examine the effect of walking before dinner on 24-h glycemic control in individuals with type 2 diabetes using the standardized multi-site Exercise-Physical Activity and Diabetes Glucose Monitoring (E-PAraDiGM) Protocol.MethodsEighty participants were studied under two conditions (exercise vs. non-exercise control) separated by 72h in a randomized crossover design. Each condition lasted 2days during which standardized meals were provided. Exercise consisted of 50min of treadmill walking at 5.0km/h before the evening meal, while control involved 50min of sitting. The primary outcome measure was mean glucose during the 24-h period following exercise (or sitting) measured by continuous glucose monitoring.ResultsOf the 80 participants who were initially randomized, 73 completed both exercise and control. Sixty-three participants [29 males, 34 females; age=648years, body mass index=30.56.5kg/m(2) and HbA1c=51 +/- 8mmol/mol (6.8 +/- 0.7%), mean +/- SD] complied with the standardized diets and had complete continuous glucose monitoring data. Exercise did not affect mean 24-h glucose compared to control (0.03mmol/L; 95% CI -0.17, 0.22, P=0.778) but individual differences between conditions ranged from -2.8 to +1.8mmol/L. Exercise did not affect fasting glucose, postprandial glucose or glucose variability. Glucose concentrations measured by continuous glucose monitoring were reduced during the 50min of walking in exercise compared to sitting in control (-1.56mmol/L; 95% CI -2.18, -0.95, p<0.001).Conclusion Contrary to previous acute exercise studies, 50min of walking before dinner in the E-PAraDiGM protocol did not affect 24-h glucose profiles. However, highly heterogeneous responses to exercise were observed.Trial registration: NCT02834689.