Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 11, Issue 20, Pages 18103-18110Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b01615
Keywords
organic phosphorescence; organic semiconductor; time-resolved luminescence imaging; photodynamic therapy; crystal engineering
Funding
- National Natural Science Foundation of China [21875104, 51673095, 21507098, 91833304]
- National Basic Research Program of China (973 Program) [2015CB932200]
- Natural Science Fund for Distinguished Young Scholars of Jiangsu Province [BK20180037]
- Primary Research & Development Plan of Jiangsu Province [BE2016770]
- Natural Science Fund for Colleges and Universities of Jiangsu Province [17KJB430020]
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Developing highly efficient red metal-free organic phosphors for biological applications is a formidable challenge. Here, we report a novel molecular design principle to obtain red metal-free organic phosphors with long emission lifetime (504.6 mu s) and high phosphorescence efficiency (14.6%) from the isolated molecules in the crystal. Furthermore, the well-dispersed phosphorescent nanodots (PNDs) with the particle size around 5 nm are prepared through polymer-encapsulation in an aqueous solution, which show good biocompatibility and low cytotoxicity. The metal-free PNDs are successfully applied to time-resolved luminescence imaging to eliminate background fluorescence interference both in vitro and vivo as well as effective photodynamic anticancer therapy for the first time. This work will not only pave a pathway to develop highly efficient metal-free RTP materials but also expand the scope of their applications to biomedical fields.
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