Journal
ACS APPLIED MATERIALS & INTERFACES
Volume 11, Issue 18, Pages 16320-16327Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acsami.9b02643
Keywords
conjugated oligomer; hydrogel; antibiotic-resistant bacteria; antibacteria; capture
Funding
- National Natural Science Foundation of China [21675106]
- Natural Science Basic Research Plan in Shaanxi Province of China [2017JM2019]
- Fundamental Research Funds for the Central Universities [GK201901003]
- 111 Project [B14041]
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Bacterial infection is one of main causes that threaten global human health. Especially, antibiotic-resistant bacteria like methicillin-resistant Staphylococcus aureus (MRSA) lead to high mortality rate and more expensive treatment cost. Here, a novel amino-acid-modified conjugated oligomer OTE-D-Phe was synthesized by modifying the side chain of conjugated oligo(thiophene ethynylene) with D-phenylalanine. By mixing 9-fluorenylmethyloxycarbonyl-L-phenylalanin (Fmoc-L-Phe) with OTE-D-Phe, a new and biocompatible low-molecular weight hydrogel (HG-2) was prepared through self-assembly. In solution, HG-2 can effectively capture bacteria spontaneously, such as Escherichia coli and MRSA. Most importantly, the hydrogel has specific and strong antibacterial activity against MRSA over methicillin-susceptible S. aureus, Staphylococcus epidermidis, and E. coli. Interestingly, when the hydrogel was put on a model surface, a piece of cloth, it also is able to selectively kill MRSA with low cell cytotoxicity. The antibacterial mechanism was investigated, and it demonstrated that the HG-2 interacts with and physically breaks the cell wall and membrane, which leads to MRSA death. Therefore, this new conjugated oligomer-based hydrogel provides promising applications in disinfection and therapy of MRSA in hospital and in community.
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