Journal
FOOD SCIENCE & NUTRITION
Volume 7, Issue 2, Pages 579-588Publisher
WILEY
DOI: 10.1002/fsn3.868
Keywords
body weight; chlorogenic acid; gut microbiota; obesity
Categories
Funding
- China Postdoctoral Science Foundation [2018M63072]
- Research Fund for Taiwan-Straits Postdoctoral Exchange Program [2018B003]
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To evaluate the anti-obesity effects of chlorogenic acid (CGA), the mice were fed a high-fat diet (HFD) upon chlorogenic acid treatment for 6 weeks. The results showed administration of chlorogenic acid (150 mg per kg per day) remarkably promoted body loss, reduced lipid levels in plasma and altered mRNA expression of lipogenesis and lipolysis related genes in adipose tissue. Moreover, chlorogenic acid also reversed the HFD-induced gut microbiota dysbiosis, including significantly inhibiting the growth of Desulfovibrionaceae, Ruminococcaceae, Lachnospiraceae, Erysipelotrichaceae, and raising the growth of Bacteroidaceae, Lactobacillaceae. Overall, the amelioration of HFD-induced gut microbiota dysbiosis by chlorogenic acid may contribute, at least partially, to its beneficial effects on ameliorating HFD-induced obesity.
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