Journal
BIOMEDICAL JOURNAL
Volume 42, Issue 1, Pages 27-35Publisher
ELSEVIER
DOI: 10.1016/j.bj.2018.12.001
Keywords
Oral pathogens; Systemic disease; Periodontal disease; Chronic disease; Inflammation; Dentistry
Funding
- University of the Pacific
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A growing body of literature suggests that there is a link between periodontitis and systemic diseases. These diseases include cardiovascular disease, gastrointestinal and colorectal cancer, diabetes and insulin resistance, and Alzheimer's disease, as well as respiratory tract infection and adverse pregnancy outcomes. The presence of periodontal pathogens and their metabolic by-products in the mouth may in fact modulate the immune response beyond the oral cavity, thus promoting the development of systemic conditions. A cause-and-effect relationship has not been established yet for most of the diseases, and the mediators of the association are still being identified. A better understanding of the systemic effects of oral microorganisms will contribute to the goal of using the oral cavity to diagnose and possibly treat non-oral systemic disease.
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