Journal
JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY
Volume 9, Issue 1, Pages 82-86Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jpids/piy141
Keywords
cerebrospinal fluid; matrix metalloproteinase; MMP-2; MMP-9; pediatric; tissue inhibitors of metalloproteinase; TIMP-1; TIMP-2; tuberculous meningitis
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Funding
- Wellcome Trust [084323, 104803, 203135]
- Francis Crick Institute [10218]
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We collected lumbar and ventricular cerebrospinal fluid and serum from 40 children treated for tuberculous meningitis and measured the concentrations of gelatinases and their inhibitors. The concentrations of matrix metalloproteinase 9 (MMP-9), MMP-2, tissue inhibitor of metalloproteinase 1 (TIMP-1), and TIMP-2 were significantly elevated in the lumbar CSF samples, and we found interesting dynamics for MMP-9 that offer novel insight into its role in pediatric patients with tuberculous meningitis.
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