Journal
NPJ VACCINES
Volume 4, Issue -, Pages -Publisher
NATURE PORTFOLIO
DOI: 10.1038/s41541-019-0105-9
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Funding
- National Institutes of Health [AI125623]
- Albany Medical College startup fund
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Three great plague pandemics, resulting in nearly 200 million deaths in human history and usage as a biowarfare agent, have made Yersinia pestis as one of the most virulent human pathogens. In late 2017, a large plague outbreak raged in Madagascar attracted extensive attention and caused regional panics. The evolution of local outbreaks into a pandemic is a concern of the Centers for Disease Control and Prevention (CDC) in plague endemic regions. Until now, no licensed plague vaccine is available. Prophylactic vaccination counteracting this disease is certainly a primary choice for its long-term prevention. In this review, we summarize the latest advances in research and development of plague vaccines.
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