Journal
PHARMACEUTICS
Volume 11, Issue 3, Pages -Publisher
MDPI
DOI: 10.3390/pharmaceutics11030123
Keywords
epirubicin; one-pot synthesis; silver nanoparticle; antitumor
Categories
Funding
- Natural Science Foundation of China [51428303, 81673580]
- Major Project of Hubei Province for Special Technology Innovation [2017AHB054]
Ask authors/readers for more resources
Epirubicin-capped silver nanoparticles (NPs) were synthesized through a one-pot method by using epirubicin as both the functional drug and the reducing agent of Ag+ to Ag-0. The preparation process was accomplished in 1 h. In addition, the obtained epirubicin-capped silver nanoparticle was characterized by transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDX), and infrared spectroscopy. The results showed that a layer of polymer epirubicin had formed around the silver nanoparticle, which was 30-40 nm in diameter. We further investigated the antitumor activity of the prepared epirubicin-capped silver nanoparticle, and the half maximal inhibitory concentration (IC50) against Hep G2 cells was 1.92 g/mL, indicating a good antitumor property of the nanoparticle at low dosage.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available