4.6 Review

Mitochondrial Retrograde Signalling and Metabolic Alterations in the Tumour Microenvironment

Journal

CELLS
Volume 8, Issue 3, Pages -

Publisher

MDPI
DOI: 10.3390/cells8030275

Keywords

mitochondria; retrograde signalling; metabolic reprogramming; tumour microenvironment; EMT

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Funding

  1. Basic Science Research Program, through the National Research Foundation of Korea (NRF) - Ministry of Science, ICT & Future Planning [NRF-2017R1D1A1B03029063]
  2. Korean Government [NRF-2018R1D1A1B07041381]

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This review explores the molecular mechanisms that may be responsible for mitochondrial retrograde signalling related metabolic reprogramming in cancer and host cells in the tumour microenvironment and provides a summary of recent updates with regard to the functional modulation of diverse cells in the tumour microenvironment.

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