Related references
Note: Only part of the references are listed.Glutaminase 1 expression in colorectal cancer cells is induced by hypoxia and required for tumor growth, invasion, and metastatic colonization
Lisha Xiang et al.
CELL DEATH & DISEASE (2019)
Pharmacologic Targeting of Hypoxia-Inducible Factors
Gregg L. Semenza
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 59 (2019)
HIF-1-derived cell-penetrating peptides inhibit ERK-dependent activation of HIF-1 and trigger apoptosis of cancer cells under hypoxia
Angeliki Karagiota et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2019)
Hypoxia Restrains Lipid Utilization via Protein Kinase A and Adipose Triglyceride Lipase Downregulation through Hypoxia-Inducible Factor
Ji Seul Han et al.
MOLECULAR AND CELLULAR BIOLOGY (2019)
Hallmarks of Pulmonary Hypertension: Mesenchymal and Inflammatory Cell Metabolic Reprogramming
Angelo D'Alessandro et al.
ANTIOXIDANTS & REDOX SIGNALING (2018)
Expression of AGPAT2, an enzyme involved in the glycerophospholipid/triacylglycerol biosynthesis pathway, is directly regulated by HIF-1 and promotes survival and etoposide resistance of cancer cells under hypoxia
Eleni-Anastasia Triantafyllou et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2018)
Metabolic adaptation of cancer and immune cells mediated by hypoxia-inducible factors
Debangshu Samanta et al.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2018)
Lipid Droplets in Cancer: Guardians of Fat in a Stressful World
Toni Petan et al.
MOLECULES (2018)
HIF-1-dependent lipin1 induction prevents excessive lipid accumulation in choline-deficient diet-induced fatty liver
Takatomo Arai et al.
SCIENTIFIC REPORTS (2018)
Triglycerides Promote Lipid Homeostasis during Hypoxic Stress by Balancing Fatty Acid Saturation
Daniel Ackerman et al.
CELL REPORTS (2018)
The role of hypoxia-inducible factors in metabolic diseases
Frank J. Gonzalez et al.
NATURE REVIEWS ENDOCRINOLOGY (2018)
Metabolic Reprogramming in the Heart and Lung in a Murine Model o Pulmonary Arterial Hypertension
Jose L. Izquierdo-Garcia et al.
FRONTIERS IN CARDIOVASCULAR MEDICINE (2018)
Mortalin-mediated and ERK-controlled targeting of HIF-1α to mitochondria confers resistance to apoptosis under hypoxia
Ilias Mylonis et al.
JOURNAL OF CELL SCIENCE (2017)
New horizons in hypoxia signaling pathways
Christopher W. Pugh et al.
EXPERIMENTAL CELL RESEARCH (2017)
Hypoxia-inducible protein 2 Hig2/Hilpda mediates neutral lipid accumulation in macrophages and contributes to atherosclerosis in apolipoprotein E-deficient mice
Anja Maier et al.
FASEB JOURNAL (2017)
Oxygen availability and metabolic reprogramming in cancer
Hong Xie et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2017)
The EGLN-HIF O2-Sensing System: Multiple Inputs and Feedbacks
Mircea Ivan et al.
MOLECULAR CELL (2017)
Activation of intestinal hypoxia-inducible factor 2α during obesity contributes to hepatic steatosis
Cen Xie et al.
NATURE MEDICINE (2017)
HIF drives lipid deposition and cancer in ccRCC via repression of fatty acid metabolism
Weinan Du et al.
NATURE COMMUNICATIONS (2017)
Inhibition of intracellular lipolysis promotes human cancer cell adaptation to hypoxia
Xiaodong Zhang et al.
ELIFE (2017)
Interaction between von Hippel-Lindau Protein and Fatty Acid Synthase Modulates Hypoxia Target Gene Expression
Wendi Sun et al.
SCIENTIFIC REPORTS (2017)
How lipid droplets TAG along: Glycerolipid synthetic enzymes and lipid storage
Huan Wang et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2017)
HIF3α: the little we know
Linda Ravenna et al.
FEBS JOURNAL (2016)
Hypoxia-inducible factor 3 biology: complexities and emerging themes
Cunming Duan
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2016)
Hypoxia-Inducible Factor Prolyl 4-Hydroxylase-2 Inhibition Protects Against Development of Atherosclerosis
Lea Rahtu-Korpela et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2016)
Prolyl-4 Hydroxylase 2 (PHD2) Deficiency in Endothelial Cells and Hematopoietic Cells Induces Obliterative Vascular Remodeling and Severe Pulmonary Arterial Hypertension in Mice and Humans Through Hypoxia-Inducible Factor-2α
Zhiyu Dai et al.
CIRCULATION (2016)
Deficiency of the oxygen sensor prolyl hydroxylase 1 attenuates hypercholesterolaemia, atherosclerosis, and hyperglycaemia
Elke Marsch et al.
EUROPEAN HEART JOURNAL (2016)
HIF-2α phosphorylation by CK1δ promotes erythropoietin secretion in liver cancer cells under hypoxia
Evanthia Pangou et al.
JOURNAL OF CELL SCIENCE (2016)
Protein kinase A-dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1
John W. Bullen et al.
SCIENCE SIGNALING (2016)
Protein kinase A-dependent phosphorylation stimulates the transcriptional activity of hypoxia-inducible factor 1
John W. Bullen et al.
SCIENCE SIGNALING (2016)
Hypoxia-Inducible Factors (HIFs) and Phosphorylation: Impact on Stability, Localization, and Transactivity
Thomas Kietzmann et al.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2016)
CK1δ restrains lipin-1 induction, lipid droplet formation and cell proliferation under hypoxia by reducing HIF-1α/ARNT complex formation
Maria Kourti et al.
CELLULAR SIGNALLING (2015)
Fatty acid binding protein-4 (FABP4) is a hypoxia inducible gene that sensitizes mice to liver ischemia/reperfusion injury
Bingfang Hu et al.
JOURNAL OF HEPATOLOGY (2015)
HIF2α-Dependent Lipid Storage Promotes Endoplasmic Reticulum Homeostasis in Clear-Cell Renal Cell Carcinoma
Bo Qiu et al.
CANCER DISCOVERY (2015)
Hypoxia induces a lipogenic cancer cell phenotype via HIF1α-dependent and -independent pathways
Alessandro Valli et al.
ONCOTARGET (2015)
Adipocyte Pseudohypoxia Suppresses Lipolysis and Facilitates Benign Adipose Tissue Expansion
Zoi Michailidou et al.
DIABETES (2015)
A theoretical study of lipid accumulation in the liver-implications for nonalcoholic fatty liver disease
J. Schleicher et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2014)
Increased Adipocyte O2 Consumption Triggers HIF-1α, Causing Inflammation and Insulin Resistance in Obesity
Yun Sok Lee et al.
CELL (2014)
The Metabolic Basis of Pulmonary Arterial Hypertension
Gopinath Sutendra et al.
CELL METABOLISM (2014)
Hypoxic Regulation of Glutamine Metabolism through HIF1 and SIAH2 Supports Lipid Synthesis that Is Necessary for Tumor Growth
Ramon C. Sun et al.
CELL METABOLISM (2014)
HIF and pulmonary vascular responses to hypoxia
Larissa A. Shimoda et al.
JOURNAL OF APPLIED PHYSIOLOGY (2014)
HIF-1α Expression as a Protective Strategy of HepG2 Cells Against Fatty Acid-Induced Toxicity
Wonbaek Yoo et al.
JOURNAL OF CELLULAR BIOCHEMISTRY (2014)
HIF-lα and HIF-2α are critically involved in hypoxia-induced lipid accumulation in hepatocytes through reducing PGC-lα-mediated fatty acid β-oxidation
Yanlong Liu et al.
TOXICOLOGY LETTERS (2014)
Novel roles of hypoxia response system in glucose metabolism and obesity
Toshihiro Ichiki et al.
TRENDS IN CARDIOVASCULAR MEDICINE (2014)
HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation Is Critical for Cancer Progression
De Huang et al.
CELL REPORTS (2014)
Fatty Acid Uptake and Lipid Storage Induced by HIF-1α Contribute to Cell Growth and Survival after Hypoxia-Reoxygenation
Karim Bensaad et al.
CELL REPORTS (2014)
Oxygen Sensing, Hypoxia-Inducible Factors, and Disease Pathophysiology
Gregg L. Semenza
Annual Review of Pathology-Mechanisms of Disease (2013)
Phospholipid metabolism and nuclear function: Roles of the lipin family of phosphatidic acid phosphatases
Symeon Siniossoglou
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2013)
MgcRacGAP, a cytoskeleton regulator, inhibits HIF-1 transcriptional activity by blocking its dimerization
Aggeliki Lyberopoulou et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2013)
CDK1 stabilizes HIF-1α via direct phosphorylation of Ser668 to promote tumor growth
Noel A. Warfel et al.
CELL CYCLE (2013)
In Vivo HIF-Mediated Reductive Carboxylation Is Regulated by Citrate Levels and Sensitizes VHL-Deficient Cells to Glutamine Deprivation
Paulo A. Gameiro et al.
CELL METABOLISM (2013)
Prolyl Hydroxylase Domain Protein 2 Plays a Critical Role in Diet-Induced Obesity and Glucose Intolerance
Hirohide Matsuura et al.
CIRCULATION (2013)
Dysregulated mTORC1 renders cells critically dependent on desaturated lipids for survival under tumor-like stress
Regina M. Young et al.
GENES & DEVELOPMENT (2013)
Hypoxia-inducible Factor 1α Regulates a SOCS3-STAT3-Adiponectin Signal Transduction Pathway in Adipocytes
Changtao Jiang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
TNFα induces expression of HIF-1 mRNA and protein but inhibits hypoxic stimulation of HIF-1α transcriptional activity in airway smooth muscle cells
Stamatina Tsapournioti et al.
JOURNAL OF CELLULAR PHYSIOLOGY (2013)
Selective Inhibition of Hypoxia-Inducible Factor 1α Ameliorates Adipose Tissue Dysfunction
Kai Sun et al.
MOLECULAR AND CELLULAR BIOLOGY (2013)
Activation of Hypoxia-Inducible Factor-2 in Adipocytes Results in Pathological Cardiac Hypertrophy
Qun Lin et al.
JOURNAL OF THE AMERICAN HEART ASSOCIATION (2013)
Hypoxia-Inducible Factors in Physiology and Medicine
Gregg L. Semenza
CELL (2012)
Dietary obesity-associated Hif1α activation in adipocytes restricts fatty acid oxidation and energy expenditure via suppression of the Sirt2-NAD+ system
Jaya Krishnan et al.
GENES & DEVELOPMENT (2012)
Hypoxia causes triglyceride accumulation by HIF-1-mediated stimulation of lipin 1 expression
Ilias Mylonis et al.
JOURNAL OF CELL SCIENCE (2012)
HIF-1α induction suppresses excessive lipid accumulation in alcoholic fatty liver in mice
Yasumasa Nishiyama et al.
JOURNAL OF HEPATOLOGY (2012)
The interaction of hepatic lipid and glucose metabolism in liver diseases
Lars P. Bechmann et al.
JOURNAL OF HEPATOLOGY (2012)
Reductive carboxylation supports growth in tumour cells with defective mitochondria
Andrew R. Mullen et al.
NATURE (2012)
Reductive glutamine metabolism by IDH1 mediates lipogenesis under hypoxia
Christian M. Metallo et al.
NATURE (2012)
HIF1 alpha and HIF2 alpha: sibling rivalry in hypoxic tumour growth and progression
Brian Keith et al.
NATURE REVIEWS CANCER (2012)
HIF and the Lung Role of Hypoxia-inducible Factors in Pulmonary Development and Disease
Larissa A. Shimoda et al.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2011)
Hypoxia Stimulates Low-Density Lipoprotein Receptor-Related Protein-1 Expression Through Hypoxia-Inducible Factor-1α in Human Vascular Smooth Muscle Cells
Jose Castellano et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2011)
The Differential Role of Hif1 β/Arnt and the Hypoxic Response in Adipose Function, Fibrosis, and Inflammation
Kevin Y. Lee et al.
CELL METABOLISM (2011)
Disruption of Hypoxia-Inducible Factor 1 in Adipocytes Improves Insulin Sensitivity and Decreases Adiposity in High-Fat Diet-Fed Mice
Changtao Jiang et al.
DIABETES (2011)
Hepatocyte-Specific Hypoxia-Inducible Factor-1α Is a Determinant of Lipid Accumulation and Liver Injury in Alcohol-Induced Steatosis in Mice
Bharath Nath et al.
HEPATOLOGY (2011)
Hypoxia-Inducible Transcription Factor 2α Promotes Steatohepatitis Through Augmenting Lipid Accumulation, Inflammation, and Fibrosis
Aijuan Qu et al.
HEPATOLOGY (2011)
The VLDL receptor promotes lipotoxicity and increases mortality in mice following an acute myocardial infarction
Jeanna C. Perman et al.
JOURNAL OF CLINICAL INVESTIGATION (2011)
Hypoxia promotes isocitrate dehydrogenase-dependent carboxylation of α-ketoglutarate to citrate to support cell growth and viability
David R. Wise et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
eIF2α Kinase PKR Modulates the Hypoxic Response by Stat3-Dependent Transcriptional Suppression of HIF-1α
Andreas I. Papadakis et al.
CANCER RESEARCH (2010)
Metabolic Dysfunction in the Pathogenesis of Pulmonary Hypertension
Lewis J. Rubin
CELL METABOLISM (2010)
The Asparaginyl Hydroxylase Factor Inhibiting HIF-1α Is an Essential Regulator of Metabolism
Na Zhang et al.
CELL METABOLISM (2010)
Hypoxia-inducible protein 2 is a novel lipid droplet protein and a specific target gene of hypoxia-inducible factor-1
Tina Gimm et al.
FASEB JOURNAL (2010)
Adipose Tissue-specific Inhibition of Hypoxia-inducible Factor 1α Induces Obesity and Glucose Intolerance by Impeding Energy Expenditure in Mice
Xinmei Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Plk3 Functions as an Essential Component of the Hypoxia Regulatory Pathway by Direct Phosphorylation of HIF-1α
Dazhong Xu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Casein kinase 1 regulates human hypoxia-inducible factor HIF-1
Alkmini Kalousi et al.
JOURNAL OF CELL SCIENCE (2010)
mTORC1 Signaling under Hypoxic Conditions Is Controlled by ATM-Dependent Phosphorylation of HIF-1α
Hakan Cam et al.
MOLECULAR CELL (2010)
Sirtuin 1 Modulates Cellular Responses to Hypoxia by Deacetylating Hypoxia-Inducible Factor 1α
Ji-Hong Lim et al.
MOLECULAR CELL (2010)
Fatty Acid Oxidation and Malonyl-CoA Decarboxylase in the Vascular Remodeling of Pulmonary Hypertension
Gopinath Sutendra et al.
SCIENCE TRANSLATIONAL MEDICINE (2010)
Transport of hypoxia-inducible factor HIF-1α into the nucleus involves importins 4 and 7
Georgia Chachami et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2009)
Activation of a HIF1α-PPARγ Axis Underlies the Integration of Glycolytic and Lipid Anabolic Pathways in Pathologic Cardiac Hypertrophy
Jaya Krishnan et al.
CELL METABOLISM (2009)
Targeting the hypoxia-inducible factor (HIF) pathway in cancer
Evon Poon et al.
EXPERT REVIEWS IN MOLECULAR MEDICINE (2009)
SEPT9_v1 Up-regulates Hypoxia-inducible Factor 1 by Preventing Its RACK1-mediated Degradation
Sharon Amir et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Hypoxia-Inducible Factor 2 Regulates Hepatic Lipid Metabolism
Erinn B. Rankin et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Regulation of Hypoxia-Inducible Factor 2α Signaling by the Stress-Responsive Deacetylase Sirtuin 1
Elhadji M. Dioum et al.
SCIENCE (2009)
Nuclear translocation of hypoxia-inducible factors (HIFs):: Involvement of the classical importin α/β pathway
Reinhard Depping et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH (2008)
Fatty acid synthase gene is up-regulated by hypoxia via activation of Akt and sterol regulatory element binding protein-1
Eiji Furuta et al.
CANCER RESEARCH (2008)
Atypical CRM1-dependent nuclear export signal mediates regulation of hypoxia-inducible factor-1α by MAPK
Ilias Mylonis et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Hypoxia-inducible factor-dependent degeneration, failure, and malignant transformation of the heart in the absence of the von Hippel-Lindau protein
Li Lei et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α
Jordi Rius et al.
NATURE (2008)
Hypoxia up-regulates hypoxia-inducible factor-1α transcription by involving phosphatidylinositol 3-kinase and nuclear factor κB in pulmonary artery smooth muscle cells
Rachida S. BelAiba et al.
MOLECULAR BIOLOGY OF THE CELL (2007)
Hypoxia-inducible factors: Crosstalk between their protein stability and protein degradation
Wei Wei et al.
CANCER LETTERS (2007)
Spermidine/spermine N1-acetyltransferase-1 binds to hypoxia-inducible factor-1α (HIF-1α) and RACK1 and promotes ubiquitination and degradation of HIF-1α
Jin H. Baek et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
SUMO-Specific protease 1 is essential for stabilization of HIF1α during hypoxia
Jinke Cheng et al.
CELL (2007)
Dual effect of echinomycin on hypoxia-inducible factor-1 activity under normoxic and hypoxic conditions
Benoit Vlaminck et al.
FEBS JOURNAL (2007)
RSUME, a small RWD-containing protein, enhances SUMO conjugation and stabilizes HIF-1α during hypoxia
Alberto Carbia-Nagashima et al.
CELL (2007)
SUMOylation of hypoxia-inducible factor-lα reduces its transcriptional activity
Melanie A. Berta et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
HIF-1α activation by a redox-sensitive pathway mediates cyanide-induced BNIP3 upregulation and mitochondrial-dependent cell death
L. Zhang et al.
FREE RADICAL BIOLOGY AND MEDICINE (2007)
Glycogen synthase kinase 3 phosphorylates hypoxia-inducible factor 1α and mediates its destabilization in a VHL-independent manner
Daniela Fluegel et al.
MOLECULAR AND CELLULAR BIOLOGY (2007)
Regulation of HIF-1α stability through S-nitrosylation
Fang Li et al.
MOLECULAR CELL (2007)
RACK1 competes with HSP90 for binding to HIF-1α and is required for O2-independent and HSP90 inhibitor-induced degradation of HIF-1α
Ye V. Liu et al.
MOLECULAR CELL (2007)
MgcRacGAP interacts with HIF-1 alpha and regulates its transcriptional activity
Aggeliki Lyberopoulou et al.
CELLULAR PHYSIOLOGY AND BIOCHEMISTRY (2007)
Identification of MAPK phosphorylation sites and their role in the localization and activity of hypoxia-inducible factor-1α
Ilias Mylonis et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Failure to prolyl hydroxylate hypoxia-inducible factor α phenocopies VHL inactivation in vivo
William Y. Kim et al.
EMBO JOURNAL (2006)
Hypoxia converts human macrophages into triglyceride-loaded foam cells
Pontus Bostrom et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2006)
HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption
I Papandreou et al.
CELL METABOLISM (2006)
Signalling hypoxia by HIF hydroxylases
CJ Schofield et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Negative and positive regulation of HIF-1:: A complex network
JI Bárdos et al.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER (2005)
Sumoylation increases HIF-1 stability and its transcriptional activity
SH Bae et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2004)
Regulation and destabilization of HIF-1α by ARD1-mediated acetylation
JW Jeong et al.
CELL (2002)
Inhibition of PPAR gamma 2 gene expression by the HIF-1-regulated gene DEC1/Stra13: A mechanism for regulation of adipogenesis by hypoxia
Z Yun et al.
DEVELOPMENTAL CELL (2002)
A variant of nuclear localization signal of bipartite-type is required for the nuclear translocation of hypoxia inducible factors (1α, 2α and 3α)
JC Luo et al.
ONCOGENE (2001)
Share Paper
