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Targeting the Post-Irradiation Tumor Microenvironment in Glioblastoma via Inhibition of CXCL12

Journal

CANCERS
Volume 11, Issue 3, Pages -

Publisher

MDPI
DOI: 10.3390/cancers11030272

Keywords

glioblastoma; radiotherapy; CXCL12

Categories

Funding

  1. German Research Council [RTG2099]
  2. DKFZ-MOST Cooperation in Cancer Research [CA181]

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Radiotherapy is a mainstay in glioblastoma therapy as it not only directly targets tumor cells but also depletes the tumor microvasculature. The resulting intra-tumoral hypoxia initiates a chain of events that ultimately leads to re-vascularization, immunosuppression and, ultimately, tumor-regrowth. The key component of this cascade is overexpression of the CXC-motive chemokine ligand 12 (CXCL12), formerly known as stromal-cell derived factor 1 (SDF-1). We here review the role of CXCL12 in recruitment of pro-vasculogenic and immunosuppressive cells and give an overview on future and current drugs that target this axis.

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