Journal
CANCERS
Volume 11, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/cancers11020179
Keywords
tetraspanins; cancer; Tspan8; immunotherapy; radioimmunotherapy
Categories
Funding
- INSERM-Transfert CoPOC program
- Ligue regionale contre le cancer du Puy de Dome
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Tetraspanins are exposed at the surface of cellular membranes, which allows for the fixation of cognate antibodies. Developing specific antibodies in conjunction with genetic data would largely contribute to deciphering their biological behavior. In this short review, we summarize the main functions of Tspan8/Co-029 and its role in the biology of tumor cells. Based on data collected from recently reported studies, the possibilities of using antibodies to target Tspan8 in immunotherapy or radioimmunotherapy approaches are also discussed.
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