Journal
SCIENCE ADVANCES
Volume 5, Issue 3, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.aaw0873
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Funding
- Center for Bio-Integrated Electronics at Northwestern University
- Soft and Hybrid Nanotechnology Experimental (SHyNE) Resource (NSF) [ECCS-1542205]
- Materials Research Science and Engineering Center [DMR-1720139]
- State of Illinois
- Northwestern University
- Developmental Therapeutics Core at Northwestern University
- Robert H. Lurie Comprehensive Cancer Center [NCI CA060553]
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Monitoring regional tissue oxygenation in animal models and potentially in human subjects can yield insights into the underlying mechanisms of local O-2-mediated physiological processes and provide diagnostic and therapeutic guidance for relevant disease states. Existing technologies for tissue oxygenation assessments involve some combination of disadvantages in requirements for physical tethers, anesthetics, and special apparatus, often with confounding effects on the natural behaviors of test subjects. This work introduces an entirely wireless and fully implantable platform incorporating (i) microscale optoelectronics for continuous sensing of local hemoglobin dynamics and (ii) advanced designs in continuous, wireless power delivery and data output for tether-free operation. These features support in vivo, highly localized tissue oximetry at sites of interest, including deep brain regions of mice, on untethered, awake animalmodels. The results create many opportunities for studying various O-2-mediated processes in naturally behaving subjects, with implications in biomedical research and clinical practice.
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