Journal
SCIENCE ADVANCES
Volume 5, Issue 2, Pages -Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.aau9253
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Funding
- EMBO [ALTF 57-2014]
- People Programme (Marie Curie Actions) of European Union's Eighth Framework Programme H2020 under REA grant [705930]
- BBSRC DTP scholarship [BB/J014575/1]
- Gas Safety Trust award
- Marie Curie Actions (MSCA) [705930] Funding Source: Marie Curie Actions (MSCA)
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Sleep appears to be a universally conserved phenomenon among the animal kingdom, but whether this notable evolutionary conservation underlies a basic vital function is still an open question. Using a machine learning-based video-tracking technology, we conducted a detailed high-throughput analysis of sleep in the fruit fly Drosophila melanogaster, coupled with a lifelong chronic and specific sleep restriction. Our results show that some wild-type flies are virtually sleepless in baseline conditions and that complete, forced sleep restriction is not necessarily a lethal treatment in wild-type D. melanogaster. We also show that circadian drive, and not homeostatic regulation, is the main contributor to sleep pressure in flies. These results offer a new perspective on the biological role of sleep in Drosophila and, potentially, in other species.
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